Argyria: Argyria is frequently described as a gray-blue discoloration of the skin, mucous membranes, and/or internal organs as a result of exposure to silver. Argyria may occur in an area of repeated or abrasive dermal contact with silver or silver compounds, or it may occur more extensively over widespread areas of skin after long-term oral or inhalation exposure. Localized argyria can occur in the eyes (argyrosis), where gray-blue patches of pigmentation are formed without evidence of tissue reaction. Generalized argyria is recognized by the widespread pigmentation of the skin due to the deposition of silver complexes and to a silver-induced increase in melanin Hathaway and Proctor 2004
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